WHAT ARE LIPOSOMES? Liposomes are microscopic spheres that have a natural affinity for living cells because their outer layers are composed of phospholipids that are virtually identical to the phospholipid composition of cell membranes. Nutrients that are carried by nano-sized liposomal “delivery vehicles” are very efficiently absorbed because they are...
LIPOSOMES: A CLOSER LOOK Scientists sometimes refer to liposomal agents as nanoliposomals because they are so small that they must be measured in nanometers. A nanometer (nm) is a unit of measurement that is equal to one millionth of a millimeter. Discovered in 1961 by Dr. Alec Bangham, a...
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials Subash C. Gupta, Sridevi Patchva, Bharat B. Aggarwal Abstract Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways. Extensive clinical trials over the past quarter...
Bioavailability enhancement of coenzyme Q10: an extensive review of patents. Sarwar Beg, Shamama Javed, Kanchan JKohli Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India. Abstract Coenzyme Q10 (CoQ10) is a major antioxidant principle found in human body which plays a vital role in maintaining several biochemical...
Oral Pretreatment With Liposomal Glutathione Attenuates Reperfusion Injury in Rabbit Isolated Hearts. Lauver DA, Kaissarian NM, Lucchesi BR. Source 1Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI USA. Abstract ABSTRACT: Reactive oxygen species (ROS) are a key mediator of myocardial reperfusion injury. Endogenous cellular defenses against ROS often become...
An excellent study on the characterization of liposomes and emulsion Liposome and Emulsion Characterization Direct determination of liposome nanoparticle morphology (size distribution and shape), and assembly (lamellarity) for therapeutic lipid particles are critical to characterization. These factors are known to influence biological activity, biodistribution and toxicity. Quantitative data is essential for accurate pharmaceutical and biotechnology formulation discovery...
Another great case study on the characterization of liposomes. Characterization of Liposomes in Solution The Challenge: Characterization of Liposomes in Solution A company engaged in the development of novel delivery methods for small molecule therapeutics needs accurate determinations of liposomal morphology (size distribution and shape), and assembly (lamellarity) of lipid particles. However,...
Curcumin in inflammatory diseases. Shehzad A, Rehman G, Lee YS. Source School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea. Abstract Curcumin (diferuloylmethane), a yellow coloring agent extracted from turmeric is also used as a remedy for the treatment and prevention of inflammatory diseases. Acute and chronic inflammation is...
J Alzheimers Dis. 2004 Aug;6(4):367-77; discussion 443-9. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models. Baum L, Ng A. Source Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin. lwbaum@cuhk.edu.hk Abstract Curcumin is a polyphenolic diketone from turmeric. Because of its anti-oxidant and anti-inflammatory effects, it was tested in animal models ofAlzheimer’s disease, reducing levels of amyloid and oxidized proteins and...
Invest Ophthalmol Vis Sci. 2013 Jan 8. pii: iovs.12-10647v1. doi: 10.1167/iovs.12-10647. Green tea is neuroprotective in diabetic retinopathy. Silva KC, Rosales MA, Hamassaki DE, Saito KC, Faria AM, Ribeiro PA, Lopes de Faria JB, Lopes de Faria JM. Source Renal Pathophysiology Laboratory, University of Campinas (Unicamp), Investigation on Diabetes Complications, Faculty of Medical Sciences (FCM), Campinas,...